Genetic and epigenetic concept of SARS-CoV-2 targets in different renal cancer subtypes

Abstract Objectives Recent advances in defining the genetic landscape of has shown host cell- SARS-CoV-2 interaction via ACE2 protein and presence at least three additional virus invasion genes including TMPRSS2, FURIN, CD147/BSG. In current study, we investigated mutation m-RNA expression patterns target by evaluating associations between epigenetic mechanisms susceptibility infection renal cancer subtypes. Methods We our genes. The promoter methylation profiles were tested UALCAN database. Results total rate carrying anomaly was 1.6% seven mutations, one which had a pathogenic feature, detected. analysis results groups showed that while KIRC KIRP patients lower level TMPRSS2 than healthy control, their high. KICH higher CD147/BSG group. levels reduced. Conclusions concluded may be more sensitive to infection, worsen prognosis.